SkinCeuticals Advanced RGN-6

Advanced RGN-6 Regenerative Cream – Improves 6 Visible Signs of Aging

SkinCeuticals Advanced RGN-6 is an advanced regenerative cream to visibly reverse 6 signs of aging and skin tone damage. Powered by 6 core ingredients for 6 distinct dimensions of rejuvenation, Advanced RGN-6 is developed to be used both alongside laser treatment and as part of your daily routine. When paired with laser treatments, Advanced RGN-6 optimizes rejuvenation outcomes and reduces recovery time. Physician tested with laser across all skin tones.

When used as part of a daily skincare routine, Advanced RGN-6 visibily improves 6 signs of aging and skin tone damage including visible redness, post-acne marks, dark spots, wrinkles, smoothness and firmness.

Advanced RGN-6 Daily Benefits:

• Visibly reduces redness, post-acne marks, dark spots, and wrinkles
• Improves skin smoothness and firmness
• Noticeable results in as little as 1 week

Advanced RGN-6 Post-Treatment Benefits:

• Helps calm the skin and reduce downtime
• Supports skin recovery and enhances visible results

Advanced RGN-6 Features & Benefits:

• Developed for both daily use and post-treatment use
• Helps reverse visible aging damage from 1 week with daily use
• Helps strengthen the skin barrier
• Reduces visible redness, post-acne marks, dark spots, and wrinkles with daily use
• Helps reduce downtime post procedure
• Paraben-free, fragrance-free, alcohol-free
• Ideal for all skin types, even very sensitive skin

Featured Ingredients:

• 10% Glyco-Repair™ – A nutrient-rich compound derived from carob seeds, Glycorepair™ supports skin barrier repair and promotes smoother, more refined texture.
• 1% Eperuline – Sourced from the bark of the Eperua falcata tree, Eperuline helps calm the skin, diminish visible signs of aging, and protect against oxidative stress—especially following laser treatments.
• 2% Niacinamide – Also known as Vitamin B3, Niacinamide visibly improves uneven skin tone and blotchiness while reinforcing the skin’s moisture barrier.
• 3% Acetyl Tetrapeptide-9 – A potent signaling peptide, Acetyl Tetrapeptide-9 helps strengthen the skin’s structural foundation, promoting a firmer, more resilient appearance.
• 0.2% Ectoin – An extremolyte derived from amino acids, Ectoin shields the skin from oxidative stress and environmental aggressors while helping to prevent discoloration.
• 0.2% Bioceramide-603 – A patented ceramide analog, Bioceramide-603 targets post-treatment redness and pigmentation for a more even, calm complexion.

Advanced RGN-6 is a regenerative cream inspired by laser science. When used daily it helps improve signs of aging andskin tone damage. When used post-procedure, it helps optimize rejuvenation outcomes and reduce recover post-laser recovery time.

SkinCeuticals Advanced RGN-6 Clinical Study:

Proven Power—On Its Own

In a 12-week clinical study, Advanced RGN-6 demonstrated significant improvements in key signs of daily skin aging:

• 69% reduction in visible redness
• 36% reduction in post-acne marks
• 26% reduction in dark spots
• 18% reduction in wrinkles
• 35% increase in skin smoothness
• 35% increase in firmness

Study Protocol:
A 12-week clinical evaluation involving 76 female participants, ages 35–60, with Fitzpatrick skin types I–VI. The product was applied twice daily alongside a standard cleanser and sunscreen. Results were assessed at baseline and at weeks 1, 4, 8, and 12.

Enhances Post-Treatment Recovery

Advanced RGN-6 supports faster, more complete post-procedure skin recovery—visibly reducing roughness, improving hydration, and amplifying six key signs of skin rejuvenation.

Study Protocol:
A 4-week clinical study on 35 female participants, ages 30–65, with Fitzpatrick types II and III. Participants used either the test product or a control twice daily, along with a standard cleanser and sunscreen. Following a fractional laser treatment (Halo, Sciton, 1470nm, non-ablative mode), evaluations were conducted at baseline and Day 28 using clinical grading (10-point scale), self-assessments, and both objective and subjective tolerance measures.

Accelerates Healing After Laser Procedures

In a controlled, evaluator-blinded study, Advanced RGN-6 accelerated skin recovery following laser exposure:

Study Protocol:
A single-center, randomized study involving 26 male and female participants, ages 23–50, with Fitzpatrick types I–IV. Two standardized test sites were created using a Sciton Erbium:YAG laser on the forearm. One site received Advanced RGN-6 immediately post-treatment, applied twice daily thereafter; the other site was left untreated. Healing progress was monitored via clinical and bioinstrumentation assessments at baseline, immediately post-laser, and on Days 1, 7, 11, 14, and 18. Data on file at SkinCeuticals.com

Shop SkinCeuticals products to complete your anti-aging skincare regimen.