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SkinCeuticals Discoloration Defense


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  • Targets visible skin discoloration and hyperpigmentation
  • Improves stubborn brown patches

1 fl oz


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  • SkinCeuticals Physical Fusion UV Defense SPF 50 1.7 oz full-size ($42 value)
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SkinCeuticals products can only be sold in physician offices.
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Discoloration Defense Helps Defend Your Skin Against Discoloration

SkinCeuticals Discoloration Defense is the latest-generation dark spot corrector, using a combination of potent and proven anti-discoloration ingredients—including new tranexamic acid—to address key types of skin discoloration. This layerable, daily-use hyperpigmentation and discoloration corrector is clinically proven to reduce the appearance of key types of skin discoloration, including hard-to-treat forms such as stubborn brown patches and post-acne marks.

Discoloration Defense is formulated to improve the appearance of skin discoloration, brighten skin, and even skin tone in as early as 2 weeks.

Skinceuticals Discoloration Defense Features & Benefits:

  • Features a blend of anti-discoloration ingredients to reduce the appearance of skin discoloration, improve brightness, and minimize the reoccurrence of discoloration (with continued use)
  • Improves the appearance of stubborn brown patches
  • Improves Melasma
  • Paraben-free, fragrance-free, silicone-free, gluten-free, and hydroquinone-free
  • An ideal at-home complement to professional skin discoloration treatments, such as chemical peels or non-ablative laser

Ingredient Highlights:

  • 3% Tranexamic Acid – This synthetically-derived ingredient – minimizes the reoccurrence of skin discoloration and stubborn brown patches with continued use
  • 1% Kojic Acid – Naturally produced by certain fungi – helps improve skin brightness.
  • 5% Niacinamide – Also known as vitamin B3, this water-soluble vitamin is found naturally in yeast, meat, fish, milk, eggs, green vegetables, beans, and cereal grains – brightens the skin and helps to reduce the appearance of skin discoloration.
  • 5% HEPES – This synthetically-derived acid activates natural enzymes in the skin to help break the bonds that bind dead skin cells to the surface for even exfoliation – accelerates cell turnover and enhances penetration.


Frequently Asked Questions

What is Skinceuticals Discoloration Defense?
Discoloration Defense is a potent serum formulated to address various types of skin discoloration, including dark spots, age spots, and post-inflammatory hyperpigmentation. It contains key ingredients such as tranexamic acid, niacinamide, and HEPES to target discoloration and improve skin clarity.

How does this serum help fade discoloration?
Discoloration Defense works by targeting multiple pathways involved in the formation of skin discoloration. It helps to inhibit the production of melanin, which is responsible for pigmentation and promotes exfoliation to fade existing discoloration and prevent new spots from forming.

Who can benefit from using Skinceuticals Discoloration Defense?
This serum is suitable for individuals with various types of skin discoloration, including sun spots, melasma, and post-inflammatory hyperpigmentation. It is suitable for all skin types and tones and can be used as part of a comprehensive skincare regimen.

How do I add Discoloration Defense into my skincare routine?
First, cleanse your skin. then apply your antioxidant like Phloretin CF, then apply 3-5 drops of the serum to the affected areas twice daily, morning and evening. Follow up with a moisturizer and sunscreen during the day to protect the skin from further sun damage.

SkinCeuticals Discoloration Defense is part of SkinCeutical’s pigmentation protocol which includes SkinCeuticals Phloretin CF, Glycolic 10 Renew Overnight, Glycolic Renew Cleanser, SkinCeuticals Retinol Refining Night Cream, and SkinCeuticals Phyto-A Brightening Treatment

Fade your spots with SkinCeuticals Discoloration Defense!

Complete your regimen with SkinCeutical’s products available at Rejuvent Skincare.

  • Use twice daily, am and pm.
  • Apply 3-5 drops of this skin discoloration serum to the face.
  • If using in the morning, apply after a vitamin C serum and follow with a broad spectrum SPF 50+ sunscreen.
  • Limit sun exposure while using this product.
  • Do not use it on irritated or broken skin. If irritation occurs, discontinue use.

Aqua / Water, Butylene Glycol, Niacinamide, Hydroxyethylpiperazine Ethane Sulfonic Acid, Glycerin, Tranexamic Acid, Propylene Glycol, Hydroxyethyl Urea, Kojic Acid, Caprylyl Glycol, Allantoin, Chlorphenesin, Xanthan Gum, Disodium Edta.

Ingredients may change, refer to packaging for the most current information.

  • 1 fl oz

Skin Type
  • Acne Prone

  • Aging Skin
  • All Skin Types
  • Combination
  • Congested
  • Dry
  • Mature
  • Normal
  • Oily
  • Pigment
  • Sensitive
  • Sun Damaged
  • Wrinkled
Product Type
  • Face Treatments & Serums

  • Lighteners/Brighteners
  • Acne Scars

  • Age Spots
  • Brown Pigmentation
  • Dark Spots
  • Dull Skin
  • Fine Lines
  • Hyperpigmentation
  • Irregular Texture
  • Melasma
  • Photodamage
  • Red and Brown Pigmentation
  • Red Pigmentation
  • Redness
  • Sun Damage
  • Sun Spots
  • Uneven Tone
Ingredient Preference

  • Hydroquinone-Free
  • Kojic Acid
  • Niacinamide
  • Tranexamic Acid
  • Décolleté

  • Face
  • Neck

SkinCeuticals was born from decades of skin cancer research that led to pivotal breakthroughs in antioxidants, their high potency formulas are concentrated in active ingredients and proven to penetrate optimally into the skin. Made in the USA, this medical-grade skincare is formulated to correct signs of aging, protect healthy skin, and prevent future damage. SkinCeuticals is backed by proven science to help maintain and improve skin health. These products are only available through dermatologists, plastic surgeons, spas, and other skincare professionals.

Rejuvent Skincare sells 100% authentic SkinCeuticals products and we are authorized to sell to Rejuvent’s patients. Visit SkinCeuticals to see all products.

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What others are saying

  1. Great product


    1- How is your skin? Choose skin type

    2- What is your skin's complexion? Choose complexion

    3- How are your pores? Choose pore size

    4- How is the weather where you live? Choose weather

    This product made a difference with my overall discoloration, it has great consistency and I layered it with other Skinceutical products. I will definitely purchase this product again, worth it)

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